Clinical studies | Cefaly

Clinical studies

The efficacy of CEFALY has been demonstrated by clinical studies that have been carried out since 2008. The validated results have been published in highly respected medical journals.

Acute treatment of migraine

Type of clinical study Conclusion Scientific publication
Double-blind versus placebo Sedative effect BMC Neurology 2011
Pilot open trial Effective for acute treatment of migraine attacks Neuromodulation 2017
Survey Effective for users in "real world" Acta Neurol Belg. 2017
Pivotal Randomized Double-blind versus placebo Effective and safe for acute treatment of migraine attacks Cephalalgia 2018
Pilot open trial Effective for migraine abortion ClinicalTrials. gov

Migraine Prevention

Type of clinical study Conclusion Scientific publication
Pivotal Randomized Double-blind versus placebo Effective at preventing migraine Neurology 2013
Cohort of 2300 patients Best safety for migraine treatment Journal of Headache and Pain 2013
Responders rate First line treatment Journal of Headache and Pain 2015
Prospective study on chronic migraine Effective on chronic migraine Neurological Sciences ​2017
Prospective exploratory on refractory migraine Effective on refractory migraine BMC Neurology ​2017

Neurophysiology and Mechanism of action

Type of clinical study Conclusion Scientific publication
PET Scan Central action of Cefaly Cephalalgia 2016
Action mechanism Current knowledge on mechanisms on trigeminal nerve Internal Medicine Review 2017
fMRI Central action of Cefaly Frontiers in Neurology​2017
Review Previous data confirmation Pain and Therapy journal 2015
Evoked Cortical Potential Central action of Cefaly Cephalalgia 2018
Review Rationale for electrical parameters Cephalalgia 2018